2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]pyridin-2-yl}amino)thiophene-3-carboxamide

반응식

[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6](-[c:8]2[n:9][n:10][n:11]([CH2:13][CH2:14][OH:15])[cH:12]2)[n:7]1.[NH2:16][c:17]1[s:18][c:19](-[c:25]2[c:26]([F:36])[cH:27][c:28]([C:32]([CH3:33])([CH3:34])[OH:35])[cH:29][c:30]2[F:31])[cH:20][c:21]1[C:22](=[O:23])[NH2:24]>>[c:2]1([NH:16][c:17]2[s:18][c:19](-[c:25]3[c:26]([F:36])[cH:27][c:28]([C:32]([CH3:33])([CH3:34])[OH:35])[cH:29][c:30]3[F:31])[cH:20][c:21]2[C:22](=[O:23])[NH2:24])[cH:3][cH:4][cH:5][c:6](-[c:8]2[n:9][n:10][n:11]([CH2:13][CH2:14][OH:15])[cH:12]2)[n:7]1

참가 물질

반응물 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HCID 595263122-[4-(6-Bromopyridin-2-yl)-1H-1,2,3-triazol-1-yl]ethanol

생성물 1

HCID 595257975-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]pyridin-2-yl}amino)thiophene-3-carboxamide

출처 및 근거

ORD 기록: ord-3e72f43aeccc48e5813578bbb8320e3e
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

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