2-Methoxyethylamine → 8-Indan-5-yl-2-(2-methoxy-ethylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester
반응식
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[CH2:6]([O:8][C:9]([C:11]1[C:12](=[O:34])[C:13]2[CH:18]=[N:17][C:16](S(C)(=O)=O)=[N:15][C:14]=2[N:23]([C:25]2[CH:26]=[C:27]3[C:31](=[CH:32][CH:33]=2)[CH2:30][CH2:29][CH2:28]3)[CH:24]=1)=[O:10])[CH3:7]>>[CH2:6]([O:8][C:9]([C:11]1[C:12](=[O:34])[C:13]2[CH:18]=[N:17][C:16]([NH:5][CH2:4][CH2:3][O:2][CH3:1])=[N:15][C:14]=2[N:23]([C:25]2[CH:26]=[C:27]3[C:31](=[CH:32][CH:33]=2)[CH2:30][CH2:29][CH2:28]3)[CH:24]=1)=[O:10])[CH3:7]참가 물질
3
실험 절차
Using the procedure outlined in Example 1 Step F, the title compound was prepared from 2-methoxy-ethylamine and 8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (Example 1, Step E, 10 mg, 0.022 mmol). 7 mg of 8-indan-5-yl-2-(2-methoxy-ethylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ (ppm): 9.25 (s, 1H), 8.47 (s, 1H), 7.35 (d, J=7.8 Hz, 1H), 7.22 (s, 1H), 7.14 (d, J=7.8 Hz, 1H), 5.99 (br, 2H), 4.37 (q, J=7.1 Hz, 2H), 3.45-3.35 (m, 2H), 3.29 (s, 3H), 3.00 (m, 4H), 2.18 (m, 2H), 1.38 (t, J=7.1 Hz, 3H).