참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cyclohexylamine | HCID 7965 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Ethyl 3-chloropropionate | HCID 69341 | — |
| 촉매 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 생성물 | Ethyl 3-(cyclohexylamino)propanoate | HCID 243063 | 72.3% |
반응 단계
Cyclohexylamine (0.86 g, 8.7 mmol) and 3-chloro-propionic acid ethyl ester (1.18 g, 8.67 mmol) were combined neat and K2CO3 (1.2 g, 8.7 mmol) and a catalytic amount of tetrabutylammonium iodide (ca. 5 mg) was added. The mixture was heated at 80° C. overnight. The resulting mixture was then partitioned between water and dichloromethane. The organic layer was dried (MgSO4) and concentrated to afford 1.25 g (72%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728003B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-66ca2717a0e24c2293f8cef297ade30e |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
