3-Methoxypropylamine → 8-Cyclohexyl-2-(3-methoxy-propylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester
반응식
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH2:6].[CH2:7]([O:9][C:10]([C:12]1[C:13](=[O:32])[C:14]2[CH:19]=[N:18][C:17](S(C)(=O)=O)=[N:16][C:15]=2[N:24]([CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[CH:25]=1)=[O:11])[CH3:8]>>[CH2:7]([O:9][C:10]([C:12]1[C:13](=[O:32])[C:14]2[CH:19]=[N:18][C:17]([NH:6][CH2:5][CH2:4][CH2:3][O:2][CH3:1])=[N:16][C:15]=2[N:24]([CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[CH:25]=1)=[O:11])[CH3:8]참가 물질
3
실험 절차
Using the procedure outlined in Example 28 Step F, the title compound was prepared from 3-methoxy-propylamine and 8-cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 35 (Step E) above, 30 mg, 0.08 mmol). 8-Cyclohexyl-2-(3-methoxy-propylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid (24 mg, 80%). 1H NMR (400 MHz, CDCl3) δ (ppm): 9.29 (br, 1H), 8.48 (s, 1H), 6.21 (br, 1H), 5.11 (m, 1H), 4.38 (q, J=7.1 Hz, 2H), 3.70-3.46 (m, 4H), 3.37 (s, 3H), 2.06-1.24 (m, 15H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C20H28N4O4: 389.21 (M+H). Found: 389.2.