O-Methyltyramine → 8-Cyclohexyl-5-oxo-2-[2-(4-methoxy-phenyl)-ethylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

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Using the procedure outlined in Example 28 Step F, the title compound was prepared from 2-(4-methoxy-phenyl)-ethylamine and 8-cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 35 (Step E), 35 mg, 0.09 mmol). 8-Cyclohexyl-5-oxo-2-[2-(4-methoxy-phenyl)-ethylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid (30 mg, 85%). Mass Spectrum (LCMS, ESI pos.) Calcd. For C25H30N4O4: 451.23 (M+H). Found: 451.2.

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