Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1238생성일: 2026년 10월 23일
2-Dimethylaminopyridine → (Trimethylsilyl)ethyl 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoate
https://huagongshe.com/ko/reaction/1238
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 1-(Trimethylsilyl)ethanol | HCID 12447898 | — |
| 반응물 | 4-((5,6,7,8-Tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoic acid | HCID 15345547 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (Trimethylsilyl)ethyl 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoate | HCID 54412444 | — |
반응 단계
To a solution of 0.24 g (0.73 mmol) of 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoic acid (Compound 7) in 10 ml of dry CH2Cl2 was added 0.09 g (0.74 mmol) of dimethylaminopyridine, 0.115 ml (0.80 mmol) of trimethylsilylethanol and 0.17 g (0.88 mmol) of 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride. The reaction mixture was stirred at 25° C. for 5 hours, washed with sat. aqueous NaHCO3 and brine, dried over Na2SO4 and concentrated in vacuo to an oil. Purification by flash chromatography (silica, 10% EtOAc-hexane) yielded the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05723620 |
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| 출처 데이터셋 | uspto-grants-1998_03 |
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| ORD ID | ord-558960f60108438697a2928369019551 |
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| 출처 메모 | uspto-grants-1998_03 |
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