2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid → (+/-)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-5-fluoro-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester

HRID 1239008노트

반응식

[C:21]([CH3:22])([CH3:23])([CH3:24])[O:25][C:26]([CH:27]([CH3:28])[O:29][c:30]1[cH:31][c:32]([F:38])[c:33]([CH2:36][NH2:37])[cH:34][cH:35]1)=[O:39].[CH3:59][O:60][C:61](=[O:62])[CH2:63][O:64][c:65]1[cH:66][cH:67][c:68]([CH2:69][NH2:70])[c:71]([F:72])[cH:73]1.[O:1]1[CH2:2][O:3][c:4]2[c:5]1[cH:6][cH:7][c:8]([O:10][c:11]1[c:12]([C:13](=[O:14])[OH:15])[cH:16][c:17]([F:20])[cH:18][n:19]1)[cH:9]2.[O:40]1[c:41]2[cH:42][cH:43][c:44]([O:45][c:46]3[n:47][cH:48][cH:49][cH:50][c:51]3[C:52]([OH:53])=[O:54])[cH:55][c:56]2[O:57][CH2:58]1>>[O:1]1[CH2:2][O:3][c:4]2[c:5]1[cH:6][cH:7][c:8]([O:10][c:11]1[c:12]([C:13](=[O:15])[NH:37][CH2:36][c:33]3[c:32]([F:38])[cH:31][c:30]([O:29][CH:27]([C:26]([O:25][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:39])[CH3:28])[cH:35][cH:34]3)[cH:16][c:17]([F:20])[cH:18][n:19]1)[cH:9]2