참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 3-Fluorophenol | HCID 9743 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | t-butyl (1S)-2-chloro-1-methylethylcarbamate | HCID 86761117 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | t-butyl (1S)-2-(3-fluorophenoxy)-1-methylethylcarbamate | HCID 86761118 | — |
반응 단계
To the compound (500 mg) obtained in Step 3 were added 3-fluorophenol (84 μl), potassium carbonate (250 mg) and DMF (2 ml), and the mixture was stirred overnight at 95° C. The reaction mixture was diluted with ethyl acetate. After washing with water, the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound as a crude product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728005B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-b140c6747a1a44558eefb386d2991521 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
