Dimethylformamide → t-butyl (1S)-2-(3-fluorophenoxy)-1-methylethylcarbamate

HRID 12406

반응식

HRID 12406 반응식
Cl[CH2:2][C@@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4].[F:13][C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1.C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>C(OCC)(=O)C>[F:13][C:14]1[CH:15]=[C:16]([CH:17]=[CH:18][CH:19]=1)[O:20][CH2:2][C@@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 97433-FluorophenolHCID 11430Potassium CarbonateHCID 86761117t-butyl (1S)-2-chloro-1-methylethylcarbamate

생성물 1

HCID 86761118t-butyl (1S)-2-(3-fluorophenoxy)-1-methylethylcarbamate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
95 °C

실험 절차

To the compound (500 mg) obtained in Step 3 were added 3-fluorophenol (84 μl), potassium carbonate (250 mg) and DMF (2 ml), and the mixture was stirred overnight at 95° C. The reaction mixture was diluted with ethyl acetate. After washing with water, the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound as a crude product.

후처리

  1. washAfter washing with water
  2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-b140c6747a1a44558eefb386d2991521
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728005B2

연결된 노트

불러오는 중…