Pyridine → Phenyl isoquinolin-5-ylcarbamate

HRID 12407

반응식

HRID 12407 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.Cl[C:13]([O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:14].N1C=CC=CC=1.O1CCCC1>ClCCl>[CH:7]1[C:8]2[C:3](=[C:2]([NH:1][C:13](=[O:14])[O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:11]=[CH:10][CH:9]=2)[CH:4]=[CH:5][N:6]=1

참가 물질

6

반응물 4

HCID 1049PyridineHCID 8028TetrahydrofuranHCID 15891Phenyl chloroformateHCID 707665-Aminoisoquinoline

생성물 1

HCID 11380046Phenyl isoquinolin-5-ylcarbamate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 5-aminoisoquinoline (2.7 g) were added phenyl chloroformate (2.85 ml), pyridine (2.0 ml) and tetrahydrofuran (50 ml), and the mixture was stirred for 3 hrs. The reaction mixture was diluted with dichloromethane, and washed with water and saturated aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated. Diethyl ether was added to the residue, and the precipitate was collected by filtration to give the title compound (3 g).

후처리

  1. washwashed with water and saturated aqueous sodium hydrogen carbonate
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated
  4. additionDiethyl ether was added to the residue
  5. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-aba74c00bab547b9bde785f9f9547b37
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728005B2

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