Methanol → Methyl 2-(S)-[N-carbobenzyloxy]amino-3-aminopropionate, hydrochloride

반응식

[NH2:1][CH2:2][C@H:3]([NH:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])[C:4]([OH:6])=[O:5].S(Cl)([Cl:20])=O.[CH3:22]O>>[ClH:20].[NH2:1][CH2:2][C@H:3]([NH:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])[C:4]([O:6][CH3:22])=[O:5]

참가 물질

반응물 3

HCID 887Methanol

HCID 24386Thionyl Chloride

HCID 2756313Z-Dap-OH

생성물 1

HCID 13756825Methyl 2-(S)-[N-carbobenzyloxy]amino-3-aminopropionate, hydrochloride

실험 절차

To the compound obtained in Step 1 were added methanol (100 ml) and thionyl chloride (2.4 ml), and the mixture was stirred overnight at room temperature. The solvent was evaporated to give the title compound as a crude product.

후처리

customThe solvent was evaporated

출처 및 근거

ORD 기록: ord-8a8273912e574903ba20d785b22b3f70
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07728005B2

반응 노트

불러오는 중…