Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 8-Amino-5-nitroisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 5-Nitroisoquinoline | HCID 69085 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 8-Amino-5-nitroisoquinoline | HCID 11084625 | 57.5% |
반응 단계
To 5-nitroisoquinoline (2.0 g) were added hydroxylamine hydrochloride (5.0 g) and ethanol (120 ml). A solution of sodium hydroxide (10 g) in methanol (65 ml) was slowly added at 50° C. over 90 min. The reaction mixture was poured into ice water (700 g) and the resulting precipitate was collected by filtration. The residue was washed with ethanol and dried under reduced pressure to give 8-amino-5-nitroisoquinoline (1.25 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728005B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-5e9a210e943d4c09b800007a646d13db |
| 출처 메모 | uspto-grants-2010_06 |