Ethanol → 8-Amino-5-nitroisoquinoline

HRID 12413

반응식

HRID 12413 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[CH:9]2)([O-:3])=[O:2].Cl.[NH2:15]O.C(O)C.[OH-].[Na+]>CO>[NH2:15][C:11]1[CH:12]=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[C:5]2[C:10]=1[CH:9]=[N:8][CH:7]=[CH:6]2

참가 물질

6

반응물 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 690855-NitroisoquinolineHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 110846258-Amino-5-nitroisoquinoline수율 57.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 5-nitroisoquinoline (2.0 g) were added hydroxylamine hydrochloride (5.0 g) and ethanol (120 ml). A solution of sodium hydroxide (10 g) in methanol (65 ml) was slowly added at 50° C. over 90 min. The reaction mixture was poured into ice water (700 g) and the resulting precipitate was collected by filtration. The residue was washed with ethanol and dried under reduced pressure to give 8-amino-5-nitroisoquinoline (1.25 g).

후처리

  1. filtrationthe resulting precipitate was collected by filtration
  2. washThe residue was washed with ethanol
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-5e9a210e943d4c09b800007a646d13db
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728005B2

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