2-{1-(Methoxycarbonyl)ethoxy}-3-nitropyridine → 3-Amino-2-{1-(methoxycarbonyl)ethoxy}pyridine

HRID 1241307노트

반응식

HRID 1241307 반응식
[CH3:1][O:2][C:3]([CH:5]([O:7][C:8]1[C:13]([N+:14]([O-])=O)=[CH:12][CH:11]=[CH:10][N:9]=1)[CH3:6])=[O:4]>[Pt]=O.C(O)C>[NH2:14][C:13]1[C:8]([O:7][CH:5]([C:3]([O:2][CH3:1])=[O:4])[CH3:6])=[N:9][CH:10]=[CH:11][CH:12]=1

참가 물질

4

반응물 1

HCID 219335712-{1-(Methoxycarbonyl)ethoxy}-3-nitropyridine

생성물 1

HCID 219335303-Amino-2-{1-(methoxycarbonyl)ethoxy}pyridine수율 78.7%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

A mixture of 1.7 g of 2-{1-(methoxycarbonyl)ethoxy}-3-nitropyridine, 102 mg of platinum oxide, and 7.5 ml of ethanol was stirred at room temperature under an atmosphere of hydrogen gas for 3.5 hours. The gas in the atmosphere on the reaction system was replaced with nitrogen gas, and the reaction mixture was filtered through Celite. The filtrate was concentrated. The residue was subjected to silica gel column chromatography to give 1.16 g of 3-amino-2-{1-(methoxycarbonyl)ethoxy}pyridine.

후처리

  1. filtrationthe reaction mixture was filtered through Celite
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-95bb3367e3eb4dfa9f8e38097c82f600
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115544B2

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