3-Cyanophenyl isothiocyanate → 1-(3-Cyanophenyl)-3-(1,2,2-trimethyl-propyl)-thiourea

HRID 1241615

반응식

HRID 1241615 반응식
[C:1]([C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[S:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].[CH3:12][C:13]([CH3:18])([CH3:17])[CH:14]([NH2:16])[CH3:15]>C1COCC1>[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH:16][CH:14]([CH3:15])[C:13]([CH3:18])([CH3:17])[CH3:12])=[S:11])[CH:6]=[CH:7][CH:8]=1)#[N:2]

참가 물질

4

반응물 2

HCID 765783-Cyanophenyl isothiocyanateHCID 5209072-Butanamine, 3,3-dimethyl-

생성물 1

HCID 38203771-(3-Cyanophenyl)-3-(1,2,2-trimethyl-propyl)-thiourea수율 78%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-cyanophenyl isothiocyanate (1.00 g, 6.24 mmol) in THF (25 mL) at room temperature was added (±) 3,3-dimethyl-2-aminobutane (1.08 mL, 9.36 mmol) and the reaction was stirred overnight at room temperature. The mixture was concentrated in vacuo and the resulting residue was triturated with diethyl ether and filtered to afford 1.2 g (78%) of 1-(3-cyanophenyl)-3-(1,2,2-trimethyl-propyl)-thiourea as a white solid which was used without further purification.

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe resulting residue was triturated with diethyl ether
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-c10838b872de494bbe742aea4651c8dc
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115620B2

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