Acetic Acid Mixture with Hydrobromic Acid → 3-(3-methylphenoxy)-N1-(2-nitrophenyl)-1,2-propanediamine hydrobromide

HRID 12417

반응식

HRID 12417 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[O:5][CH2:6][CH:7]([NH:19]C(=O)OCC1C=CC=CC=1)[CH2:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17].[BrH:33].C(O)(=O)C>ClCCl>[BrH:33].[CH3:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[O:5][CH2:6][CH:7]([NH2:19])[CH2:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17]

참가 물질

4

반응물 2

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 68698461Benzyl 2-(3-methylphenoxy)-1-[(2-nitroanilino)methyl]ethylcarbamate

생성물 1

HCID 686969873-(3-methylphenoxy)-N1-(2-nitrophenyl)-1,2-propanediamine hydrobromide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

To the compound obtained in Step 2 were added 30% hydrobromide/acetic acid (1 ml) and dichloromethane (2 ml), and the mixture was stirred at 0° C. for 2 hrs. The mixture was diluted with dichloromethane, and washed with saturated aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated to give the title compound as a crude product.

후처리

  1. washwashed with saturated aqueous sodium hydrogen carbonate
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-3d3cb8533ec6479193672c26c1ce3bd8
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728005B2

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