HCID 9843930, 화합물 → HCID 21936636, 화합물

HRID 1241718노트

반응식

HRID 1241718 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][N:18]=3)[CH:13]=[C:12]([CH2:20][CH2:21][CH:22]([CH3:29])[C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)[C:11]2=[O:30])[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][N:18]=3)[CH:13]=[C:12]([CH2:20][CH2:21][CH:22]([CH3:29])[C:23]3[CH:24]=[CH:25][N:26]=[CH:27][CH:28]=3)[C:11]2=[O:30])[CH:7]=[CH:8][CH:9]=1

참가 물질

3

반응물 1

HCID 9843930HCID 9843930, 화합물

생성물 1

HCID 21936636HCID 21936636, 화합물수율 89%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

The procedure of Example 7(2) was repeated using 1-(3-nitrophenyl)-3-[3-methyl-3-(pyridin-4-yl)propyl]-1,8-naphthyridin-2(1H)-one (1.19 g, 2.97 mmol; prepared in Example 11) and 10% palladium on carbon (200 mg) to obtain 1-(3-aminophenyl)-3-[3-methyl-3-(pyridin-4-yl)propyl]-1,8-naphthyridin-2(1H)-one (757 mg, 89%). The product was purified through flash column chromatography (mp 83–91° C.).

출처 및 근거

ORD 기록
ord-91519dcc0acf4cab83609eed313f91dd
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115623B2

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