Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → Methyl 4-(2-oxobutyl)-3-nitrobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Propionyl chloride | HCID 62324 | — |
| 반응물 | (E)-Methyl 4-(2-(dimethylamino)vinyl)-3-nitrobenzoate | HCID 894337 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Methyl 4-(2-oxobutyl)-3-nitrobenzoate | HCID 21938235 | — |
반응 단계
According to the method of Production Example 1, a mixed solution of methyl E-4-(2-dimethylaminovinyl)-3-nitrobenzoate (6.30 g), pyridine (3.2 ml), propionyl chloride (3.26 g) and methylene chloride (60 ml) is heated under reflux for 11 hours, and then heated under reflux with 1,4-dioxane in water for 16 hours to obtain methyl 4-(2-oxobutyl)-3-nitrobenzoate (5.63 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07115647B2 |
| 출처 데이터셋 | uspto-grants-2006_10 |
| ORD ID | ord-44241f6f06f8418bbcc629a864c0f360 |
| 출처 메모 | uspto-grants-2006_10 |