2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde → [2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-methanol

HRID 1242290노트

반응식

HRID 1242290 반응식
[CH3:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:3]=1.C[Mg]Cl>C1COCC1>[CH3:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[CH:11]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 219356242-Methyl-6-(3-trifluoromethyl-phenyl)-pyridine-3-carbaldehydeHCID 178418332HCID 178418332, 화합물

생성물 1

HCID 21935815[2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

0.500 g (1.89 mmol) of the above prepared 2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde was dissolved in 9.4 ml of abs. THF and treated at −10° C. with 0.94 ml of 3M methyl magnesium chloride solution (in THF). After 30 Min., the reaction mixture was carefully poured onto crashed ice/NH4Cl, extracted twice with AcOEt, washed with water, dried over sodium sulfate, and evaporated to dryness to leave 0.532 g of the title product, pure according to NMR.

후처리

  1. dissolutionwas dissolved in 9.4 ml of abs
  2. addition, the reaction mixture was carefully poured
  3. extractionextracted twice with AcOEt
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-74950623264f439a9ef3f0974e9a6f9e
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115611B2

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