HCID 21638546, 화합물 → HCID 67072407, 화합물
반응식
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:8]=1[O:14][CH3:15])[CH3:2].Cl[CH2:18][C:19]1[C:20]([CH3:35])=[N:21][C:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)=[CH:23][CH:24]=1>>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:18][C:19]2[C:20]([CH3:35])=[N:21][C:22]([C:25]3[CH:26]=[CH:27][C:28]([C:31]([F:34])([F:32])[F:33])=[CH:29][CH:30]=3)=[CH:23][CH:24]=2)=[CH:9][C:8]=1[O:14][CH3:15])[CH3:2]참가 물질
3
실험 절차
In analogy to the procedures described in examples 8A] and 31B], 3-(4-hydroxy-2-methoxy-phenyl)-propionic acid ethyl ester was reacted with 3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (example 1N]) to give 3-{2-methoxy-4-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-phenyl}-propionic acid ethyl ester, which was subsequently saponified to yield the title compound as colorless solid.
출처 및 근거
- ORD 기록
- ord-cb7d524260ae4afbaab957cc3a145290
- 출처 데이터셋
- uspto-grants-2006_10