Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1242443생성일: 2026년 10월 26일
Potassium Phosphate, Tribasic → 3-Pyridinecarboxylic acid,4-(trifluoromethyl)-6-[4-(trifluoromethyl)phenyl]-,methyl ester
https://huagongshe.com/reaction/1242443
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| 반응물 | Methyl 6-chloro-4-(trifluoromethyl)nicotinate | HCID 2775340 | — |
| 촉매 | Dichlorobis(triphenylphosphine)palladium | HCID 6102075 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 3-Pyridinecarboxylic acid,4-(trifluoromethyl)-6-[4-(trifluoromethyl)phenyl]-,methyl ester | HCID 76852878 | 70.9% |
반응 단계
A solution of 0.84 g (1.2 mmol) bis(triphenylphosphine)palladium(II)chloride, 9.58 g (40 mmol) methyl 6-chloro-4-(trifluoromethyl)nicotinate and 10.08 g (52 mmol) of 4-(trifluoromethyl)benzeneboronic acid in 200 ml degassed toluene was treated with 40 ml aqueous 2M K3PO4 and heated at 80° C. for 16 h. The reaction was cooled to RT and extracted with H2O (0° C.)/Et2O (3x). The organic phases were washed with aqueous 10% NaCl, dried (NaSO4) and evaporated. Purification by flash-chromatography on silica gel (dichloromethane/heptane 2:1 to 1:1) gave 9.91 g of the title compound as an off-white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07115611B2 |
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| 출처 데이터셋 | uspto-grants-2006_10 |
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| ORD ID | ord-de3bc50f33be4802bc7fd4fe69c091e5 |
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| 출처 메모 | uspto-grants-2006_10 |
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