Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 3-Hydroxyphenylacetate → 2-Methyl-2-(3-{[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylcarbamoyl]-methyl}-phenoxy)-propionic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 3-Hydroxyphenylacetate | HCID 39129 | — |
| 반응물 | tert-Butyl 2-bromo-2-methylpropionate | HCID 90290 | — |
| 반응물 | 3-(1-tert-Butoxycarbonyl-1-methylethoxy)phenylacetic Acid | HCID 18766414 | — |
| 반응물 | 2-Methyl-6-(4-(trifluoromethyl)phenyl)pyridin-3-amine | HCID 21935832 | — |
| 생성물 | 2-Methyl-2-(3-{[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylcarbamoyl]-methyl}-phenoxy)-propionic acid tert-butyl ester | HCID 67072142 | — |
반응 단계
In analogy to the procedures described in example 26B] and 124C], 2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylamine (example 125C]) was reacted with 2-(3-carboxymethyl-phenoxy)-2-methyl-propionic acid tert-butyl ester (prepared from (3-hydroxy-phenyl)-acetic acid methyl ester and tert-butyl alpha-bromoisobutyrate, in analogy to the procedure described in example 52A], followed by saponification in analogy the procedure described in example 124A]) to give 2-methyl-2-(3-{[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylcarbamoyl]-methyl}-phenoxy)-propionic acid tert-butyl ester, which was subsequently cleaved with trifluoroacetic acid to yield the title compound as light yellow amorphous solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07115611B2 |
| 출처 데이터셋 | uspto-grants-2006_10 |
| ORD ID | ord-11bb8b44725045a4b42af22100163a60 |
| 출처 메모 | uspto-grants-2006_10 |