Ethylamine → Ethyl N-ethyl-beta-alaninate

HRID 1242537

반응식

HRID 1242537 반응식
[CH2:1]([NH2:3])[CH3:2].[C:4]([O:8][CH2:9][CH3:10])(=[O:7])[CH:5]=[CH2:6]>O1CCCC1>[CH2:1]([NH:3][CH2:6][CH2:5][C:4]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2]

참가 물질

4

반응물 2

HCID 6341EthylamineHCID 8821Ethyl Acrylate

생성물 1

HCID 90223Ethyl N-ethyl-beta-alaninate수율 84%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To 110 ml of a 2M solution of ethyl amine in tetrahydrofuran (THF) at 0° C. was added dropwise ethyl acrylate (8.0 ml, 73.92 mmol) in 40 ml of tetrahydrofuran (THF). The reaction mixture was stirred overnight at room temperature. The reaction solution was filtered through a cotton wool plug and concentrated under reduced pressure to yield the title compound 10 (9.01 g, 84%) as a clear liquid. υmax/cm−1 3319.68, 2969.10, 1732.07, 1191.87 (FT-IR: FIG. 8)

후처리

  1. filtrationThe reaction solution was filtered through a cotton wool plug
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-383003a242bc45d6a333bad977610657
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115718B2

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