Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Phenylbenzoyl chloride → (3Ez,5s)-1-([1,1'-biphenyl]-4-ylcarbonyl)-5-[3-(2-thienylmethyl)-1,2,4-oxadiazol-5-yl]-3-pyrrolidinone o-methyloxime
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Phenylbenzoyl chloride | HCID 84151 | — |
| 반응물 | N'-Hydroxy-2-(2-thienyl)ethanimidamide | HCID 2737293 | — |
| 반응물 | (2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid | HCID 58714586 | — |
| 생성물 | (3Ez,5s)-1-([1,1'-biphenyl]-4-ylcarbonyl)-5-[3-(2-thienylmethyl)-1,2,4-oxadiazol-5-yl]-3-pyrrolidinone o-methyloxime | HCID 58714508 | — |
반응 단계
Following the general method as outlined in Example 59, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidine-carboxylic acid (Intermediate 2), [1,1′-biphenyl]-4-carbonyl chloride, and N′-hydroxy-2-(2-thienyl)ethanimidamide, the title compound was obtained in 85% purity by HPLC. MS(ESI+): m/z=459.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07115639B2 |
| 출처 데이터셋 | uspto-grants-2006_10 |
| ORD ID | ord-fb02a62e7ab94362b285a8913080bc0d |
| 출처 메모 | uspto-grants-2006_10 |