Boron tribromide → 8-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

HRID 1243132

반응식

HRID 1243132 반응식
C[O:2][C:3]([CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[C:8]([O:15]C)[CH:9]=[CH:10][CH:11]=2)[CH2:6]1)=[O:4].B(Br)(Br)Br>ClCCl>[OH:15][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:7]=1[CH2:6][CH:5]([C:3]([OH:4])=[O:2])[CH2:14][CH2:13]2

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 13058286Methyl 8-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

생성물 1

HCID 219404338-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid수율 77%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 8-Methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid methyl ester (660 mg, 3.0 mmol) in dichloromethane (3.0 mL) was added BBr3 (1 M, 3.0 mL, 3.0 mmol) at −78° C. The mixture was stirred for 3 hour and then worked up to give 8-hydroxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (470 mg, 2.3 mmol, 77%).

출처 및 근거

ORD 기록
ord-09b52fc89f3f48d18289b28fd48140d8
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115767B2

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