2-Bromopyridine → 1-(PYRIDIN-2-YL)-1,4-DIAZEPANE

HRID 1243328노트

반응식

HRID 1243328 반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1>O>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

참가 물질

4

반응물 2

HCID 79732-BromopyridineHCID 68163Hexahydro-1,4-diazepine

생성물 1

HCID 27724021-(PYRIDIN-2-YL)-1,4-DIAZEPANE

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2-bromopyridine and 12 g of homopiperazine is heated at 100° C. for 6 hours. 50 ml of water are added to the reaction mixture and the resulting mixture is extracted with EtOAc, the organic phase is washed with saturated NaCl solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 1.28 g of the expected product are obtained.

후처리

  1. extractionthe resulting mixture is extracted with EtOAc
  2. washthe organic phase is washed with saturated NaCl solution
  3. dry with materialdried over Na2SO4
  4. customthe solvent is evaporated off under vacuum

출처 및 근거

ORD 기록
ord-6e8e0d76255349c9aaacd4e64da19443
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07119086B2

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