1,4-Dioxane hydrochloride → 6-(Aminomethyl)nicotinonitrile hydrochloride

반응식

O1CCOCC1.[ClH:7].C(OC([N:15]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][N:25]=1)C(OC(C)(C)C)=O)=O)(C)(C)C>>[ClH:7].[NH2:15][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][N:25]=1

참가 물질

반응물 2

HCID 204431481,4-Dioxane hydrochloride

HCID 53802151HCID 53802151, 화합물

생성물 1

HCID 219277836-(Aminomethyl)nicotinonitrile hydrochloride

실험 절차

2-Aminomethyl-5-cyanopyridine hydrochloride (EX-58A) was prepared by the deprotection with 4N HCl Dioxane of the intermediate 2-{N,N-bis-(tert-butoxycarbonyl)aminomethyl}-5-cyanopyridine used to prepare 2-aminomethyl-5-carbobenzyloxyamidinopyridine dihydrogen chloride salt in Example 56:1H NMR (400 MHz, DMSO) d 9.04 (s, 1H), 8.64 (br s, 2H), 834 (m, 1H), 7.69 (m, 1H), 4.25 (s, 2H); HRMS (EI) calcd for C7H8N3 134.0718, found 134.0699.

출처 및 근거

ORD 기록: ord-e14c9b0bd09a48168aa28e7f301cfb9f
출처 데이터셋: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07119094B1

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