Methyl 4-fluorobenzoylacetate → 1-(5-Chloro-2,4-dimethoxy-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid

HRID 12439

반응식

HRID 12439 반응식
[N:1]([C:4]1[CH:9]=[C:8]([Cl:10])[C:7]([O:11][CH3:12])=[CH:6][C:5]=1[O:13][CH3:14])=[N+:2]=[N-:3].C[O:16][C:17](=[O:28])[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=1)=O.[O-]CC.[Na+]>CCO>[Cl:10][C:8]1[C:7]([O:11][CH3:12])=[CH:6][C:5]([O:13][CH3:14])=[C:4]([N:1]2[C:19]([C:21]3[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=3)=[C:18]([C:17]([OH:28])=[O:16])[N:3]=[N:2]2)[CH:9]=1

참가 물질

5

반응물 3

HCID 579425Methyl 4-fluorobenzoylacetateHCID 2723922Sodium ethoxideHCID 587310171-Azido-5-chloro-2,4-dimethoxybenzene

생성물 1

HCID 587310181-(5-Chloro-2,4-dimethoxy-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1-Azido-5-chloro-2,4-dimethoxy-benzene (0.4 g, 1.9 mmol), 3-(4-Fluoro-phenyl)-3-oxo-propionic acid methyl ester (0.42 g, 2.2 mmol) and sodium ethoxide in EtOH (70 mg of sodium in 15 mL EtOH) were refluxed for 3 hours. During the reaction, the solution turned brown from dark green. After that, EtOH was evaporated off and the resulting oil was dried in vacuum. Trituration with ether (15 mL) gave light brown solids, which were removed by filtration and washed with ether. The solids then re-dissolved in CHCl3 and filtered. After evaporation of the solvent, light brown solids were obtained (0.35 g, 50%).

후처리

  1. customDuring the reaction
  2. customAfter that, EtOH was evaporated off
  3. customthe resulting oil was dried in vacuum
  4. customTrituration with ether (15 mL) gave light brown solids, which
  5. customwere removed by filtration
  6. washwashed with ether
  7. dissolutionThe solids then re-dissolved in CHCl3
  8. filtrationfiltered
  9. customAfter evaporation of the solvent
  10. customlight brown solids were obtained (0.35 g, 50%)

출처 및 근거

ORD 기록
ord-7a8b9422f4634db6947a7b29d86ba228
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728016B2

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