Trifluoroacetic acid → 1,1-Dimethyl-4-nitro-butylamine trifluoroacetate

HRID 1244080노트

반응식

HRID 1244080 반응식
C(OC(=O)[NH:7][C:8]([CH3:16])([CH3:15])[CH2:9][CH2:10][CH2:11][N+:12]([O-:14])=[O:13])(C)(C)C.[C:18]([OH:24])([C:20]([F:23])([F:22])[F:21])=[O:19]>C(Cl)Cl>[F:21][C:20]([F:23])([F:22])[C:18]([OH:24])=[O:19].[CH3:15][C:8]([NH2:7])([CH3:16])[CH2:9][CH2:10][CH2:11][N+:12]([O-:14])=[O:13]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86587889HCID 86587889, 화합물

생성물 1

HCID 219316631,1-Dimethyl-4-nitro-butylamine trifluoroacetate수율 88%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To (1,1-Dimethyl-4-nitro-butyl)-carbamic acid tert-butyl ester (1.0 g, 4.0 mmol) in 25 mL CH2Cl2 at −10° C. was added 2.5 mL TFA. The mixture was warmed to rt and monitored by TLC. When judged complete by TLC analysis, the mixture was concentrated to give the 518 mg (88%) of the title compound as an orange oil: mass spectrum m/e=147 (M+1).

후처리

  1. concentrationthe mixture was concentrated

출처 및 근거

ORD 기록
ord-cf4b506976344b1b80f8586c74ed6fea
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07119207B2

반응 노트

불러오는 중…