Allyl bromide → 1-[3-(Allyloxy)phenyl]ethanone
반응식
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]([OH:10])[CH:9]=1)=[O:3].C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][CH:19]=[CH2:20]>CC(C)=O>[CH2:20]([O:10][C:8]1[CH:9]=[C:4]([C:2](=[O:3])[CH3:1])[CH:5]=[CH:6][CH:7]=1)[CH:19]=[CH2:18]참가 물질
5
실험 절차
To solution of 3-hydroxyacetophenone (2.140 g, 15.72 mmol) in acetone (100 mL) was added potassium carbonate (4.344 g, 31.43 mmol), and 3-bromo-propene (2.282 g, 18.86 mmol) and the reaction was stirred at room temperature for 16 h. The solvent was removed in vacuo and water (25 mL) was added to the reaction mixture and then extracted with ethyl acetate (3×60 mL). The organic extracts were washed with brine (15 mL), dried (Na2SO4) and concentrated to give the title compound which was used as is in the next step.
후처리
- customThe solvent was removed in vacuo and water (25 mL)
- additionwas added to the reaction mixture
- extractionextracted with ethyl acetate (3×60 mL)
- washThe organic extracts were washed with brine (15 mL)
- dry with materialdried (Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-8d3c60a8585e4faca3a916616cb0bc63
- 출처 데이터셋
- uspto-grants-2006_10
- 특허 번호
- US07119205B2
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