Diethylamine → HCID 85961308, 화합물

HRID 1244256

반응식

HRID 1244256 반응식
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[CH2:6]([O:8][C:9]([C:11]1[N:12]=[N:13][C:14]([Cl:18])=[CH:15][C:16]=1Cl)=[O:10])[CH3:7]>C(OCC)(=O)C>[CH2:6]([O:8][C:9]([C:11]1[N:12]=[N:13][C:14]([Cl:18])=[CH:15][C:16]=1[N:3]([CH2:4][CH3:5])[CH2:1][CH3:2])=[O:10])[CH3:7]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 53428795Ethyl 4,6-dichloropyridazine-3-carboxylate

생성물 1

HCID 85961308HCID 85961308, 화합물수율 98.1%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Diethylamine (86 mg, 1.3 equivalents, 1.2 mmol) is added to a solution of 4,6-dichloro-pyridazine-3-carboxylic acid ethyl ester (0.2 g, 0.91 mmol) in ethyl acetate (10 mL) at room temperature. After overnight stirring, the reaction is quenched with water (6 mL). The organic layer is separated and the aqueous layer extracted (2×15 mL) with ethyl acetate. The combined organic layers are dried and solvent removed to give 230 mg of 6-chloro-4-diethylamino-pyridazine-3-carboxylic acid ethyl ester as a yellowish oil.

후처리

  1. customthe reaction is quenched with water (6 mL)
  2. customThe organic layer is separated
  3. extractionthe aqueous layer extracted (2×15 mL) with ethyl acetate
  4. customThe combined organic layers are dried
  5. customsolvent removed

출처 및 근거

ORD 기록
ord-9e8b97256656485b83fc086a99a545bc
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07122546B2

연결된 노트

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