3-(Pyrimidin-2-yl)prop-2-yn-1-ol → 2-Pyrimidinepropanol

HRID 1244428노트

반응식

HRID 1244428 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]#[C:8][CH2:9][OH:10]>C(OCC)(=O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][OH:10]

참가 물질

4

반응물 1

HCID 219193933-(Pyrimidin-2-yl)prop-2-yn-1-ol

생성물 1

HCID 109755572-Pyrimidinepropanol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

3-(2-pyrimidyl)prop-2-yn-1-ol (4.45 g, 0.033 M) was dissolved in ethyl acetate (140 mL), 10% Pd/C (890 mg) was added and the mixture stirred under an atmosphere of hydrogen for 6 hours. The reaction mixture was filtered through Celite and the filtrate evaporated to give 3-(2-pyrimidyl)propan-1-ol as a yellow oil, 4.15 g (91%). NMR (CDCl3) 2.1 (2H, m), 3.2 (2H, t), 3.8 (2H, t), 7.2 (1H, t), 8.7 (2H, d) MS found MH+ 139.

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe filtrate evaporated

출처 및 근거

ORD 기록
ord-0b25e8604be04407bb231ee0410487a2
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07122551B2

반응 노트

불러오는 중…