Methyl Acetate → methyl 4-nitrobenzimidate
반응식
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:12](OC)(=[O:14])C>CO>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8](=[NH:9])[O:14][CH3:12])=[CH:10][CH:11]=1)([O-:3])=[O:2]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
Part A: 4-Nitrobenzonitrile (5.4 g, 36.5 mmol) was dissolved in 200 mL of anhydrous methyl acetate and 20 mL of MeOH. The whole mixture was cooled to 0° C. and bubbled with dry HCL gas for 1 hour. The resulting mixture was placed at 5° C. for 12 hours, the solvent was removed to obtain 5.8 g of methyl 4-nitrobenzimidate as its HCl salt.
후처리
- custombubbled
- customwith dry HCL gas for 1 hour
- customthe solvent was removed
출처 및 근거
- ORD 기록
- ord-83d01c69039f43258e1cf79ef71734e0
- 출처 데이터셋
- uspto-grants-2006_10
- 특허 번호
- US07122557B2
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