2-Oxo-2-(thiophen-2-yl)acetaldehyde → 4-(7-Thiophen-2-yl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-ylmethyl)-phenol

HRID 1244633노트

반응식

HRID 1244633 반응식
O=[C:2]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)[CH:3]=O.[NH2:10][N:11]1[C:15]([NH2:16])=[N:14][N:13]=[C:12]1[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1>>[S:6]1[CH:7]=[CH:8][CH:9]=[C:5]1[C:2]1[CH:3]=[N:10][N:11]2[C:12]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=3)=[N:13][N:14]=[C:15]2[N:16]=1

참가 물질

3

반응물 2

HCID 52722142-Oxo-2-(thiophen-2-yl)acetaldehydeHCID 219193134-[(4,5-Diamino-4H-1,2,4-triazol-3-yl)methyl]phenol

생성물 1

HCID 219193214-(7-Thiophen-2-yl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-ylmethyl)-phenol

실험 절차

General procedure A was followed with the reaction of oxo-thiophen-2-yl-acetaldehyde and 4-(4,5-diamino-4H-[1,2,4]triazol-3-ylmethyl)-phenol to provide 4-(7-thiophen-2-yl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-ylmethyl)-phenol and the desired product 4-(6-thiophen-2 -yl[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-ylmethyl)-phenol (example 2).

출처 및 근거

ORD 기록
ord-03ac5f06536542a5886268203b362e3c
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07122548B2

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