Phenylglyoxal → 3-(4-Fluoro-benzyl)-7-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazine

반응식

O=[C:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH:3]=O.[F:11][C:12]1[CH:25]=[CH:24][C:15]([CH2:16][C:17]2[N:18]([NH2:23])[C:19]([NH2:22])=[N:20][N:21]=2)=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:25]=[CH:24][C:15]([CH2:16][C:17]2[N:18]3[N:23]=[CH:3][C:2]([C:5]4[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=4)=[N:22][C:19]3=[N:20][N:21]=2)=[CH:14][CH:13]=1

참가 물질

반응물 2

HCID 14090Phenylglyoxal

HCID 219193225-[(4-Fluorophenyl)methyl]-4H-1,2,4-triazole-3,4-diamine

생성물 1

HCID 219193173-(4-Fluoro-benzyl)-7-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazine

실험 절차

General procedure A was followed with the reaction of oxo-phenyl-acetaldehyde and 5-(4-fluoro-benzyl)-[1,2,4]triazole-3,4-diamine to provide 3-(4-fluoro-benzyl)-7-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazine and the desired product 3-(4-fluoro-benzyl)-6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazine (example 4).

출처 및 근거

ORD 기록: ord-61c720a8e1f049ccae42ee87b9b460c5
출처 데이터셋: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07122548B2

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