Benzyl Bromide → 3-Benzyl-4-methoxy-1,3-dihydro-indol-2-one

HRID 1244842노트

반응식

[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][C:6](=[O:12])[NH:7]2.[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([CH:5]1[C:4]2[C:8](=[CH:9][CH:10]=[CH:11][C:3]=2[O:2][CH3:1])[NH:7][C:6]1=[O:12])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

반응물 2

HCID 7498Benzyl Bromide

HCID 5960014-Methoxy-2-indolinone

생성물 1

HCID 219232533-Benzyl-4-methoxy-1,3-dihydro-indol-2-one수율 73%

실험 절차

3-Benzyl-4-methoxy-1,3-dihydro-indol-2-one is prepared from 4-methoxyoxindole (4.8 mmol) and benzyl bromide (5.3 mmol) substantially as described above for Epoxide 4. The compound is purified by flash chromatography (SiO2, 25% ethyl acetate:hexane) to obtain the desired compound (36%). MS (ESI+) 254.

후처리

customThe compound is purified by flash chromatography (SiO2, 25% ethyl acetate:hexane)

출처 및 근거

ORD 기록: ord-bdc39819da3e477fa7e28ddd26541e28
출처 데이터셋: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07122680B2

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