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Water → 2-chloro-N-[2-[(2-chloro-9-cyclopentyl-9H-purin-6-yl)-amino]-ethyl]-4-nitro-benzamide

HRID 1244960
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HRID 1244960 반응식
[NH2:1][CH2:2][CH2:3][NH:4][C:5]1[N:13]=[C:12]([Cl:14])[N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[CH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1.[CH2:20]([Cl:22])Cl.C(N(CC)CC)C.Cl[C:31]1[C:39]([N+:40]([O-:42])=[O:41])=[CH:38][CH:37]=[CH:36][C:32]=1C(Cl)=O.[OH2:43]>>[Cl:22][C:20]1[CH:38]=[C:39]([N+:40]([O-:42])=[O:41])[CH:31]=[CH:32][C:36]=1[C:37]([NH:1][CH2:2][CH2:3][NH:4][C:5]1[N:13]=[C:12]([Cl:14])[N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[CH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1)=[O:43]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 5

HCID 962WaterHCID 6344DichloromethaneHCID 8471TriethylamineHCID 126274132-Chloro-3-nitrobenzoyl chlorideHCID 21922924N-(2-aminoethyl)-2-chloro-9-cyclopentyl-9H-purin-6-amine

생성물 1

HCID 219229622-chloro-N-[2-[(2-chloro-9-cyclopentyl-9H-purin-6-yl)-amino]-ethyl]-4-nitro-benzamide

실험 절차

280 mg of the product obtained in Stage 1 of Example 7, 4 ml of methylene chloride, 0.28 ml of triethylamine and 264 mg of 2-chloronitrobenzoyl chloride are mixed together then the reaction medium is agitated at ambient temperature for 3 hours. Then 2 ml of water is added, followed by extracting with methylene chloride, drying and evaporating the solvents. In this way 295 mg of expected product is obtained.

후처리

  1. extractionby extracting with methylene chloride
  2. customdrying
  3. customevaporating the solvents

출처 및 근거

ORD 기록
ord-f5d30d40e3224d30a95244b6500caf97
출처 데이터셋
uspto-grants-2006_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07122669B1

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