Methyl 1-benzyloxycarbonylindoline-2-carboxylate → HCID 57457959, 화합물

HRID 1245042노트

반응식

HRID 1245042 반응식
CO[C:3](=O)[C@@H:4]1[CH2:8][C:7](=[CH2:9])[CH2:6][N:5]1[C:10](OCC1C=CC=CC=1)=O.[CH2:21]([O:28]C(N1C2C(=CC=CC=2)CC1C(OC)=O)=O)[C:22]1C=CC=CC=1>>[CH2:9]=[C:7]1[CH2:6][N:5]2[C@H:4]([CH2:3][C:21](=[O:28])[CH2:22][CH2:10]2)[CH2:8]1

참가 물질

3

반응물 2

HCID 12153759Methyl 1-benzyloxycarbonylindoline-2-carboxylateHCID 54190049(S)-1-Benzyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate

생성물 1

HCID 57457959HCID 57457959, 화합물수율 61%

실험 절차

In a similar manner to the procedures described in Preparative Examples 5(i)′ and 5(ii) above, reduction, methanesulfonylation and cyanogenation were conducted, using (S)-1-benzyloxycarbonyl-4-methylideneproline methyl ester [obtained as described in Preparative Example 8(i)′ above], instead of methyl 1-benzyloxycarbonylindoline-2-carboxylate, to give the title compound as a colorless oil (yield: 61%).

후처리

  1. customobtained

출처 및 근거

ORD 기록
ord-ff80bc77a3554abfbb9029d5b81ba0ee
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07122666B2

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