(S)-1-Benzyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate → HCID 57457961, 화합물

반응식

CO[C:3](=O)[C@@H:4]1[CH2:8][C:7](=[CH:9][CH3:10])[CH2:6][N:5]1[C:11](OCC1C=CC=CC=1)=O.C[O:23][C:24](=O)[C@@H:25]1CC(=C)CN1C(OCC1C=CC=CC=1)=O>>[CH2:9]([C@@H:7]1[CH2:6][N:5]2[C@H:4]([CH2:3][C:24](=[O:23])[CH2:25][CH2:11]2)[CH2:8]1)[CH3:10]

참가 물질

반응물 2

HCID 54190049(S)-1-Benzyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate

HCID 69558769HCID 69558769, 화합물

생성물 1

HCID 57457961HCID 57457961, 화합물수율 10%

실험 절차

In a similar manner to the procedures described in. Preparative Examples 8(ii)′, 8(iii)′, 8(iv)′, 8(v)′ and 8(vi)′ above, reactions were conducted in turn, using (S)-1-benzyloxycarbonyl-4-ethylideneproline methyl ester [prepared as described in Preparative Example 24′ above] instead of (S)-1-benzyloxycarbonyl-4-methylideneproline methyl ester, to give the title compound as a brown oil (yield: 10%).

후처리

customprepared

출처 및 근거

ORD 기록: ord-754e786f52404ff8aec0b97b636cad3f
출처 데이터셋: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07122666B2

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