반응식
[NH2:1][C:2]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][C:3]=1[C:4]([NH:6][CH:7]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:14][CH:13]=1)[C:8]([OH:10])=[O:9])=[O:5].[CH3:36][CH2:37][CH2:38][CH2:39][N:40]([C:45]1[C:50]2[CH:51]=[CH:52][CH:53]=[C:54]([S:55](Cl)(=[O:57])=[O:56])[C:49]=2[CH:48]=[CH:47][CH:46]=1)[CH2:41][CH2:42][CH2:43][CH3:44].[CH2:59](Cl)Cl>>[CH3:59][O:9][C:8](=[O:10])[C@@H:7]([NH:6][C:4](=[O:5])[C:3]1[CH:31]=[C:32]([Cl:35])[CH:33]=[CH:34][C:2]=1[NH:1][S:55]([C:54]1[C:49]2[C:50](=[C:45]([N:40]([CH2:41][CH2:42][CH2:43][CH3:44])[CH2:39][CH2:38][CH2:37][CH3:36])[CH:46]=[CH:47][CH:48]=2)[CH:51]=[CH:52][CH:53]=1)(=[O:57])=[O:56])[CH2:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[CH:16][CH:17]=1참가 물질
4
반응물 3
생성물 1
실험 절차
A solution of 2-(2-amino-5-chloro-benzoylamino)-3-(2′-phenoxy-biphenyl-4-yl)-propionic acid (0.05 g, 0.1 mmol) [prepared by reacting (2S)-amino-3-(2′-phenoxy-biphenyl-4-yl)propionic acid methyl ester hydrochloride salt and 2-amino-5-chlorobenzoic acid by general procedure A] in CH2Cl2 was treated with (0.035 g, 0.1 mmol) of bansyl chloride according to the general procedure F. Product was purified by flash column chromatography on silicagel using ethyl acetate hexanes to give product as pale yellow solid (0.06 g, 74.0% yield).
후처리
- customProduct was purified by flash column chromatography on silicagel
출처 및 근거
- ORD 기록
- ord-3324280800134e06b46e14dc221a2c32
- 출처 데이터셋
- uspto-grants-2006_10
- 특허 번호
- US07122580B2
연결된 노트
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