참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 1-Naphthaleneboronic acid | HCID 254532 | — |
| 반응물 | Ethyl 5-bromo-4-methylthiazole-2-carboxylate | HCID 59338079 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-Methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid ethyl ester | HCID 59338449 | — |
반응 단계
To a solution of 5-bromo-4-methyl-thiazole-2-carboxylic acid ethyl ester (60 mg, 0.24 mmol) in 1,4-dioxane (2 ml) is added 1-naphthaleneboronic acid (50 mg, 0.29 mmol), cesium carbonate (187 mg, 0.58 mmol) and Pd(PPh3)4 (28 mg, 0.024 mmol). The reaction mixture is stirred in a sealed tube at 110° C. overnight. After cooling to rt, the mixture is purified by PTLC to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728009B1 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-9f1c3eae5e914686a5941e976dd60d69 |
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| 출처 메모 | uspto-grants-2010_06 |
|---|
