Hydantoin → 1-[(4-Methoxyphenyl)methyl]imidazolidine-2,4-dione

HRID 1245331노트

반응식

HRID 1245331 반응식
[NH:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].C([O-])([O-])=O.[Cs+].[Cs+].[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20]Cl)=[CH:18][CH:17]=1>CN(C=O)C.[Cl-].[Na+].O>[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][N:1]2[CH2:5][C:4](=[O:6])[NH:3][C:2]2=[O:7])=[CH:18][CH:17]=1

참가 물질

6

반응물 3

HCID 10006HydantoinHCID 10796Cesium carbonateHCID 699934-Methyloxybenzyl chloride

생성물 1

HCID 219110281-[(4-Methoxyphenyl)methyl]imidazolidine-2,4-dione

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 57417360Sodium chloride; water용매

실험 절차

A mixture of imidazolidine-2,4-dione (5.01 g), Cs2CO3, and 4-methoxybenzyl chloride (8.0 mL) in DMF (250 mL) was allowed to react overnight. The reaction was added to 400 mL brine then extracted with ether. The desired product precipitated from the ether, and was collected by filtration to yield 1-(4-methoxybenzyl)-imidazolidine-2,4-dione as a white solid.

후처리

  1. customto react overnight
  2. extractionthen extracted with ether
  3. customThe desired product precipitated from the ether
  4. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-ba3e2795c759446fa485ec76e48a605a
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07125865B2

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