Dihydrouracil → 3-(3-{[7-Propyl-3-(phenyl)-1,2-benzisoxazol-6-yl]oxy}propyl)-dihydropyrimidine-2,4(1h,3h)-dione
반응식
N1CCC(=O)NC1=O.[CH3:9][C:10]1(C2C=CC=CC=2)[NH:14][C:13](=[O:15])[N:12]([CH2:16][CH2:17][CH2:18][O:19][C:20]2[CH:34]=[CH:33][C:23]3[C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[N:25][O:26][C:22]=3[C:21]=2[CH2:35][CH2:36][CH3:37])[C:11]1=[O:38]>>[CH2:35]([C:21]1[C:22]2[O:26][N:25]=[C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:23]=2[CH:33]=[CH:34][C:20]=1[O:19][CH2:18][CH2:17][CH2:16][N:12]1[C:11](=[O:38])[CH2:10][CH2:9][NH:14][C:13]1=[O:15])[CH2:36][CH3:37]참가 물질
3
실험 절차
3-(3-{[7-Propyl-3-(phenyl)-1,2-benzisoxazol-6-yl]oxy}propyl)dihydropyrimidine-2,4(1H,3H)-dione was prepared as for Example 10 from dihydropyrimidine-2,4(1H,3H)-dione and the bromide from Example 27. After aqueous work-up and silica gel chromatography, the title compound was obtained.
출처 및 근거
- ORD 기록
- ord-5ef6a4c1ea114b8f8404c2d10eb3660c
- 출처 데이터셋
- uspto-grants-2006_10