Acrolein dimethyl acetal → 4-[4-(5-Dimethoxymethyl-4,5-dihydro-isoxazol-3-yl)-phenoxymethyl]-2-methyl-quinoline

HRID 1245392

반응식

HRID 1245392 반응식
[CH3:1][O:2][CH:3]([O:6][CH3:7])[CH:4]=[CH2:5].[CH3:8][C:9]1[CH:18]=[C:17]([CH2:19][O:20][C:21]2[CH:29]=[CH:28][C:24]([CH:25]=[N:26][OH:27])=[CH:23][CH:22]=2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1>>[CH3:1][O:2][CH:3]([O:6][CH3:7])[CH:4]1[O:27][N:26]=[C:25]([C:24]2[CH:23]=[CH:22][C:21]([O:20][CH2:19][C:17]3[C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[N:10]=[C:9]([CH3:8])[CH:18]=3)=[CH:29][CH:28]=2)[CH2:5]1

참가 물질

3

반응물 2

HCID 80145Acrolein dimethyl acetalHCID 738530794-(2-Methyl-quinolin-4-ylmethoxy)-benzaldehyde oxime

생성물 1

HCID 219111774-[4-(5-Dimethoxymethyl-4,5-dihydro-isoxazol-3-yl)-phenoxymethyl]-2-methyl-quinoline수율 100%

실험 절차

Following a procedure analogous to that used in Example step 1c, but using 3,3-dimethoxy-propene and 4-(2-methyl-quinolin-4-ylmethoxy)-benzaldehyde oxime from step 1b, the crude reaction was partitioned between ethyl acetate and water and the organic layer was washed with brine, dried over magnesium sulfate, and concentrated to give 4-[4-(5-dimethoxymethyl-4,5-dihydro-isoxazol-3-yl)-phenoxymethyl]-2-methyl-quinoline (0.4 g, 100%) as a crude oil. MS found: (M+H)+=393.

후처리

  1. customthe crude reaction
  2. customwas partitioned between ethyl acetate and water
  3. washthe organic layer was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4924a64531f34706a08014fded8fd5f9
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07125870B2

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