Methyl butadienecarboxylate → HCID 69640073, 화합물

HRID 1245397노트

반응식

HRID 1245397 반응식
[CH3:1][O:2][C:3](=[O:8])[CH:4]=[CH:5][CH:6]=[CH2:7].[CH3:9][C:10]1[CH:19]=[C:18]([CH2:20][O:21][C:22]2[CH:30]=[CH:29][C:25]([CH:26]=[N:27][OH:28])=[CH:24][CH:23]=2)[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1>>[CH3:1][O:2][C:3](=[O:8])[CH:4]=[CH:5][CH:6]1[O:28][N:27]=[C:26]([C:25]2[CH:24]=[CH:23][C:22]([O:21][CH2:20][C:18]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[N:11]=[C:10]([CH3:9])[CH:19]=3)=[CH:30][CH:29]=2)[CH2:7]1

참가 물질

3

반응물 2

HCID 73688Methyl butadienecarboxylateHCID 738530794-(2-Methyl-quinolin-4-ylmethoxy)-benzaldehyde oxime

생성물 1

HCID 69640073HCID 69640073, 화합물수율 73%

실험 절차

Following a procedure analogous to that used in Example step 1c, but using penta-2,4-dienoic acid methyl ester and 4-(2-methyl-quinolin-4-ylmethoxy)-benzaldehyde oxime from step 1b, the crude reaction was partitioned between ethyl acetate and water, and the organic layer was washed with brine, dried over magnesium sulfate, and concentrated to give 3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-acrylic acid methyl ester (2.57 g, 73%) as a white powder. MS found: (M+H)+=403.

후처리

  1. customthe crude reaction
  2. customwas partitioned between ethyl acetate and water
  3. washthe organic layer was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d0507e7b1ec34244903438c05c721aa7
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07125870B2

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