3-Chloro-2-methylbenzenesulfonyl chloride → 3-Chloro-N-(4-ethyl-5-methyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide

반응식

[CH2:1]([C:3]1[N:4]=[C:5]([NH2:9])[S:6][C:7]=1[CH3:8])[CH3:2].[Cl:10][C:11]1[C:12]([CH3:21])=[C:13]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:15][CH:16]=1>>[Cl:10][C:11]1[C:12]([CH3:21])=[C:13]([S:17]([NH:9][C:5]2[S:6][C:7]([CH3:8])=[C:3]([CH2:1][CH3:2])[N:4]=2)(=[O:19])=[O:18])[CH:14]=[CH:15][CH:16]=1

참가 물질

반응물 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chloride

HCID 31640224-Ethyl-5-methyl-1,3-thiazol-2-amine

생성물 1

HCID 99236013-Chloro-N-(4-ethyl-5-methyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide수율 12%

실험 절차

The title compound was prepared from 4-ethyl-5-methyl-1,3-thiazol-2-ylamine (METHOD I) and 3-chloro-2-methylbenzenesulfonyl chloride according to METHOD A, yellowish foam, 40 mg (12% yield): HRMS Calcd (found) for C13H15ClN2O2S2 m/z 330.0263 (330.0271).

출처 및 근거

ORD 기록: ord-961f8344607a4c57ad038b2b79d97588
출처 데이터셋: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07125900B2

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