4-Bromophenacyl bromide → 1-(4-Bromophenyl)-2-morpholinoethanone

HRID 1245870노트

반응식

HRID 1245870 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)=[O:10]>C1(C)C=CC=CC=1>[Br:17][C:14]1[CH:15]=[CH:16][C:11]([C:9](=[O:10])[CH2:8][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 74544-Bromophenacyl bromideHCID 8083Morpholine

생성물 1

HCID 4108821-(4-Bromophenyl)-2-morpholinoethanone수율 101.3%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

Morpholine (4.35 g) in dry toluene (8 ml) was stirred during the addition of aliquots of 2-bromo-1-(4-bromophenyl)ethanone (6.95 g) in dry toluene (70 ml). The resulting precipitate was removed by filtration and the filtrate evaporated to give the product (J. Amer. Chem. Soc., 1940, 62, 2882) as a pale yellow solid (7.2 g).

후처리

  1. customThe resulting precipitate was removed by filtration
  2. customthe filtrate evaporated

출처 및 근거

ORD 기록
ord-0da871f3069a4a07b9e014cbe6805ccb
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07125896B2

반응 노트

불러오는 중…