Thionyl Chloride → 2-Chloro-5-chloromethyl-6-trifluoromethyl-1-(2,4,6-trimethyl-phenyl)-1H-imidazo[1,2-a]imidazole

HRID 1246320노트

반응식

HRID 1246320 반응식
[Cl:1][C:2]1[N:3]([C:16]2[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][C:17]=2[CH3:24])[C:4]2[N:5]([CH:15]=1)[C:6]([CH2:13]O)=[C:7]([C:9]([F:12])([F:11])[F:10])[N:8]=2.S(Cl)([Cl:27])=O>ClCCl>[Cl:1][C:2]1[N:3]([C:16]2[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][C:17]=2[CH3:24])[C:4]2[N:5]([C:6]([CH2:13][Cl:27])=[C:7]([C:9]([F:12])([F:11])[F:10])[N:8]=2)[CH:15]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 21916271[6-chloro-2-trifluoromethyl-7-(2,4,6-trimethyl-phenyl)-7H-imidazo[1,2-a]imidazol-3-yl]-methanol

생성물 1

HCID 219160952-Chloro-5-chloromethyl-6-trifluoromethyl-1-(2,4,6-trimethyl-phenyl)-1H-imidazo[1,2-a]imidazole수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of [6-chloro-2-trifluoromethyl-7-(2,4,6-trimethyl-phenyl)-7H-imidazo[1,2-a]imidazol-3-yl]-methanol (614.8 mg, 1.718 mmol) and thionyl chloride (1.25 mL) in dichloromethane was stirred at 0° C. for 15 min. Thionyl chloride and the solvent were removed in vacuo and the residue was dried under high vacuum to yield the desired product as a yellow solid (646.3 mg, 100%). LC/MS: tR=1.46 min., MS: [MH−Cl+OMe]=373.

후처리

  1. customThionyl chloride and the solvent were removed in vacuo
  2. customthe residue was dried under high vacuum

출처 및 근거

ORD 기록
ord-bb9bb23b16dd43909225d98b3cea8c01
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07125990B2

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