Potassium Carbonate → N-[4-(Hydroxymethyl)-1,3-thiazol-2-YL]acetamide
반응식
C([O:4][CH2:5][C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:14])[CH3:13])[S:9][CH:10]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:14])[CH3:13])[S:9][CH:10]=1참가 물질
4
실험 절차
A mixture of (2-(acetylamino)-1,3-thiazol-4-yl)methyl acetate (46 g) and potassium carbonate (30 g) in methanol (640 ml) was stirred for 3 hours at ambient temperature. The reaction mixture was concentrated in vacuo. The residue was diluted with chloroform, and the insoluble material was filtered off. The resulting solution was purified by flash column chromatography on silica-gel with methanol/chloroform (1/99). The resulted solid was collected by filtration with isopropyl ether to give N-(4-(hydroxymethyl)-1,3-thiazol-2-yl)acetamide (35 g) as white crystals.
후처리
- concentrationThe reaction mixture was concentrated in vacuo
- additionThe residue was diluted with chloroform
- filtrationthe insoluble material was filtered off
- customThe resulting solution was purified by flash column chromatography on silica-gel with methanol/chloroform (1/99)
- filtrationThe resulted solid was collected by filtration with isopropyl ether
출처 및 근거
- ORD 기록
- ord-e25449450da046fc98a4239639a3803e
- 출처 데이터셋
- uspto-grants-2006_10
- 특허 번호
- US07125901B2
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