Pyridine → Ethyl 2-acetamido-1,3-thiazole-4-carboxylate

HRID 1246438노트

반응식

HRID 1246438 반응식
Br.[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:7]=1.N1C=CC=CC=1.[C:19](Cl)(=[O:21])[CH3:20]>ClCCl>[C:19]([NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:7]=1)(=[O:21])[CH3:20]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 16495520Ethyl 2-aminothiazole-4-carboxylate hydrobromide

생성물 1

HCID 702548Ethyl 2-acetamido-1,3-thiazole-4-carboxylate수율 88.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To an ice-cold mixture of ethyl 2-amino-1,3-thiazole-4-carboxylate hydrobromide (80 g), pyridine (52.5 g) and dichloromethane (800 ml) was added acetyl chloride (27.3 g) dropwise at 0° C., and the mixture was stirred for 30 minutes at the same temperature. The reaction mixture was washed with water (500 ml), dried over sodium sulfate and concentrated in vacuo. The crystalline residue was collected and washed with ethyl acetate to give ethyl 2-(acetylamino)-1,3-thiazole-4-carboxylate (60 g).

후처리

  1. washThe reaction mixture was washed with water (500 ml)
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated in vacuo
  4. customThe crystalline residue was collected
  5. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-1ea586f789ba4d6abd8147139c3201a0
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07125901B2

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